omega-Conotoxin MVIIA (omega conotoxin MVIIA)

Catalog No. ABIN1540040

Quick Overview for omega-Conotoxin MVIIA (omega conotoxin MVIIA) (ABIN1540040)

Target: omega-Conotoxin MVIIA

Application: Blocking Reagent (BR)

Product Details

Purpose: omega-Conotoxin MVIIA is a Cav2.2 channel blocker

Sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys25

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: omega-Conotoxin MVIIA

Background: Omega-Conotoxin MVIIA has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B). Omega-conotoxin MVIIA is available under the name Prialt by Neurex. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.

Molecular Weight: 2639.18 Da

CAS-No: 107452-89-1